ea0032p72 | Bone and Osteoporosis | ECE2013
Shankarnarayan Santosh H
, Ahluwalia Rupa
, Hamilton Amanda
, Barraclough Dong L
, Fraser William D
, Vora Jiten P
Introduction: It is recognised that osteocytes, by secreting sclerostin plays a more central role in bone homeostasis. Sclerostin is a physiological inhibitor of bone formation. By binding to the LRP5/6 receptor sclerostin inhibits the Wnt signalling pathway. A cross-sectional study was undertaken to ascertain whether an endogenous sclerostin circadian rhythm exists in healthy individuals.Subjects and methods: Six healthy young men with normal BMD were a...